- Academic Editor
-
-
-
Announcements
Open Access
Review
Redox TRPs in Ischemia-Reperfusion Injury and Their Pharmacological Value
Show Less
1
Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022 Wuhan, Hubei, China
*Correspondence: dryaolijun@163.com (Li-Jun Yao)
Front. Biosci. (Landmark Ed) 2024, 29(5), 170;
https://doi.org/10.31083/j.fbl2905170
Submitted: 27 October 2023 | Revised: 26 February 2024 | Accepted: 18 March 2024 | Published: 30 April 2024
Copyright: © 2024 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract
Ischemia-reperfusion injury (IRI) is a complex phenomenon. Although researchers have long been aware of IRI, its complex signaling events and potential therapeutic targets are still an active research area. The role of reactive oxygen species in IRI has garnered great interest among scientists. Recent studies have found that reactive oxygen species produced by IRI can activate redox-sensitive transient receptor potential channels (redox TRPs). The discovery of redox TRPs provides a new perspective for understanding the mechanism of IRI.
Keywords
ischemia reperfusion injury
reactive oxygen species
transient receptor potential channels
redox-sensitive TRP channels
Funding
81974102/National Nature Science Foundation of China
Figures
Fig. 1.